The Evaluation of Lipoma Arborescens with Intermittent Knee Joint Effusion Based on an Analysis of Serum Cytokine Levels and an Immunohistological Examination

  • Umetsu Ayaka
    Department of Rheumatology, Sasebo Chuo Hospital, Japan
  • Eguchi Katsumi
    Department of Rheumatology, Sasebo Chuo Hospital, Japan
  • Koga Tomohiro
    Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Araki Takeshi
    Department of Rheumatology, Sasebo Chuo Hospital, Japan
  • Takatani Ayuko
    Department of Rheumatology, Sasebo Chuo Hospital, Japan
  • Aramaki Toshiyuki
    Department of Rheumatology, Sasebo Chuo Hospital, Japan
  • Terada Kaoru
    Department of Rheumatology, Sasebo Chuo Hospital, Japan
  • Iwamoto Naoki
    Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Miyahara Kenji
    Department of Orthopedic Surgery, Sasebo Chuo Hospital, Japan
  • Yonemitsu Nobuhisa
    Department of Pathology, Sasebo Chuo Hospital, Japan
  • Nakamura Hideki
    Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan
  • Kawakami Atsushi
    Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
  • Ueki Yukitaka
    Department of Rheumatology, Sasebo Chuo Hospital, Japan

抄録

<p>We herein report a 27-year-old woman who presented with recurrent knee pain. Laboratory findings revealed minimal inflammation. Arthrography revealed structures resembling adipose tissues. Magnetic resonance imaging showed a high signal intensity of these structures, leading to the diagnosis of lipoma arborescens (LA). Synovectomy was performed. Pathology revealed adipocyte proliferation and B-cell clusters but no T-cell infiltration. A serum cytokine analysis revealed low levels of interleukin-6 and tumor necrosis factor-α compared with patients with rheumatoid arthritis. The pathogenesis of LA remains unclear, but immunostaining and serum cytokine levels may provide valuable data for future investigations. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 63 (9), 1305-1309, 2024-05-01

    一般社団法人 日本内科学会

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