The Evaluation of Lipoma Arborescens with Intermittent Knee Joint Effusion Based on an Analysis of Serum Cytokine Levels and an Immunohistological Examination
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- Umetsu Ayaka
- Department of Rheumatology, Sasebo Chuo Hospital, Japan
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- Eguchi Katsumi
- Department of Rheumatology, Sasebo Chuo Hospital, Japan
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- Koga Tomohiro
- Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
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- Araki Takeshi
- Department of Rheumatology, Sasebo Chuo Hospital, Japan
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- Takatani Ayuko
- Department of Rheumatology, Sasebo Chuo Hospital, Japan
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- Aramaki Toshiyuki
- Department of Rheumatology, Sasebo Chuo Hospital, Japan
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- Terada Kaoru
- Department of Rheumatology, Sasebo Chuo Hospital, Japan
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- Iwamoto Naoki
- Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
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- Miyahara Kenji
- Department of Orthopedic Surgery, Sasebo Chuo Hospital, Japan
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- Yonemitsu Nobuhisa
- Department of Pathology, Sasebo Chuo Hospital, Japan
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- Nakamura Hideki
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Japan
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- Kawakami Atsushi
- Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
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- Ueki Yukitaka
- Department of Rheumatology, Sasebo Chuo Hospital, Japan
抄録
<p>We herein report a 27-year-old woman who presented with recurrent knee pain. Laboratory findings revealed minimal inflammation. Arthrography revealed structures resembling adipose tissues. Magnetic resonance imaging showed a high signal intensity of these structures, leading to the diagnosis of lipoma arborescens (LA). Synovectomy was performed. Pathology revealed adipocyte proliferation and B-cell clusters but no T-cell infiltration. A serum cytokine analysis revealed low levels of interleukin-6 and tumor necrosis factor-α compared with patients with rheumatoid arthritis. The pathogenesis of LA remains unclear, but immunostaining and serum cytokine levels may provide valuable data for future investigations. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (9), 1305-1309, 2024-05-01
一般社団法人 日本内科学会