Clinical Utility of Flow Cytometry for Detection of Anti-Jk<sup>b</sup> IgM in Acute Haemolytic Transfusion Reaction
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- Nagaharu Keiki
- Department of Hematology, Mie University Hospital, Japan Department of Hematology, Yokkaichi Municipal Hospital, Japan Department of Hematology, Japanese Red Cross Ise Hospital, Japan
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- Izumi Takuya
- Department of Hematology, Japanese Red Cross Ise Hospital, Japan
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- Maruyama Mitsuko
- Transfusion Medicine and Cell Therapy, Mie University Hospital, Japan
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- Sugimoto Yuka
- Department of Hematology, Mie University Hospital, Japan
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- Ohishi Kohshi
- Transfusion Medicine and Cell Therapy, Mie University Hospital, Japan
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- Tawara Isao
- Department of Hematology, Mie University Hospital, Japan
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- Usui Eiji
- Department of Hematology, Japanese Red Cross Ise Hospital, Japan
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- Tamaki Shigehisa
- Department of Hematology, Japanese Red Cross Ise Hospital, Japan
抄録
<p>Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests, the 37°C normal saline test was weakly positive for Jkb. We confirmed the presence of anti-Jkb IgM in the patient's serum by flow cytometry. This case demonstrates the potential utility of flow cytometry for IgM detection. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (9), 1273-1275, 2024-05-01
一般社団法人 日本内科学会