A potentiostat readout array for nanopore-based DNA sequencing

DOI Web Site 28 References
  • Wang Yirun
    School of Microelectronics, Xidian University
  • Jin Gang
    School of Microelectronics, Xidian University
  • Tang Hualian
    School of Microelectronics, Xidian University
  • Wu Hao
    School of Computer Science, Xi’an Shiyou University
  • Liu Weifeng
    School of Microelectronics, Xidian University

Abstract

<p>Nanopore-based DNA sequencing technology features the advantages of label-free, low-cost, and rapid detection. However, the existing nanopore sequencing readout cell or array for the lower area and power consumption become prohibitive. This brief presents a low noise potentiostat readout array. Based on the five-transistor OPA, the half-shared amplifier reduces the area and power consumption of the cell by about 50%, and shows a good suppression effect on mid-to-high frequency noise in the output channel. As a result, high-throughput is achieved with low noise. The performance of the proposed array channel has been evaluated in 180-nm CMOS process, the input-referred current transient noise was 2.28pARMS, the power consumption was 2.2µW and the unit area was 10×12µm2.</p>

Journal

  • IEICE Electronics Express

    IEICE Electronics Express 21 (9), 20240118-20240118, 2024-05-10

    The Institute of Electronics, Information and Communication Engineers

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