Unraveling the Mystery of Membrane-less Organelles within Cells

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Other Title
  • 膜のない細胞小器官の謎に迫る
  • マク ノ ナイ サイボウ ショウキカン ノ ナゾ ニ セマル

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Description

<p>Membraneless organelles (MLOs) are condensates that compartmentalize and thereby facilitate specific biological functions. Multivalent interactions between RNA and protein components elicit phase separation to form MLOs. Many MLOs are multiple-layered, and the physiological properties of each layer contribute to MLO functions. MLOs sequestrate specific factors to promote/suppress the biological reaction in which they are involved. MLOs are also known to associate with specific chromosomal loci to place genes in the appropriate sub-nuclear environment for regulating their expression. Reflecting the physiological importance of MLOs, aberrant morphologies of MLOs and mutations in MLO components have been reported in various tumors and diseases.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 64 (2), 71-77, 2024

    The Biophysical Society of Japan General Incorporated Association

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