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Innate Antiviral Response through Mitochondrial Antiviral Signaling Protein (MAVS) in Fish - A Review
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- Prasad Kurcheti Pani
- ICAR- Central Institute of Fisheries Education
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- Krishnan Rahul
- ICAR- Central Institute of Fisheries Education
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- Uthaman Shyam Kokkattunivarthil
- ICAR- Central Institute of Fisheries Education
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- Kezhedath Jeena
- ICAR- Central Institute of Fisheries Education
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- Kumar Pokanti Vinay
- ICAR- Central Institute of Fisheries Education
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Description
<p>The innate antiviral response through the RIG-1-like receptor pathway is oriented towards a key regulatory molecule, mitochondrial antiviral signaling protein (MAVS). Localized to the mitochondria, MAVS coordinates the interferons (IFN) production through regulated signaling cascades. Protein-protein interaction, post-translational modifications, and mitochondrial dynamics considerably regulate MAVS signaling on the mitochondrial membrane. This review gives insight into the inevitable role of MAVS in the innate antiviral immune response of fish.</p>
Journal
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- Fish Pathology
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Fish Pathology 59 (2), 39-53, 2024-06-15
The Japanese Society of Fish Pathology