Innate Antiviral Response through Mitochondrial Antiviral Signaling Protein (MAVS) in Fish - A Review

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<p>The innate antiviral response through the RIG-1-like receptor pathway is oriented towards a key regulatory molecule, mitochondrial antiviral signaling protein (MAVS). ​Localized to the mitochondria, MAVS coordinates the interferons (IFN) production through regulated signaling cascades. ​Protein-protein interaction, post-translational modifications, and mitochondrial dynamics considerably regulate MAVS signaling on the mitochondrial membrane. ​This review gives insight into the inevitable role of MAVS in the innate antiviral immune response of fish.</p>

Journal

  • Fish Pathology

    Fish Pathology 59 (2), 39-53, 2024-06-15

    The Japanese Society of Fish Pathology

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