A case of germline <i>BRCA2</i> mutated hormone receptor-positive breast cancer with multiple recurrent liver metastases in the early postoperative period and long-term response to olaparib as first-line treatment

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  • 術後早期に多発性肝転移再発を認めた<i>BRCA2</i>病的バリアントを有するホルモン受容体陽性乳癌に対して，一次治療としてオラパリブが長期間奏効した1例

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<p>　We report a case of germline BRCA2 mutated hormone receptor-positive breast cancer with multiple recurrent liver metastases in the early postoperative period that showed a long-term response to first-line olaparib treatment. The patient was diagnosed with left breast cancer (cT4dN1M0, Stage ⅢB, Luminal B type) at the age of 32. After neoadjuvant chemotherapy, she underwent surgery, and the pathology assessment indicated pCR. Seven months after surgery, multiple liver metastases and germline BRCA2 mutation are revealed and the patient was treated with olaparib as primary therapy. Three years and 10 months later, one 3-cm liver metastasis was found in S5 of the liver. Radiofrequency ablation was performed after biopsy of the liver tumor. Olaparib was continued and no relapse was observed 5 months after ablation. Early administration of olaparib may improve the long-term prognosis in patients with germline BRCA mutation, even in patients with a short disease-free interval and poor prognosis with liver metastases.</p>

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