Hemoglobin Level Can Predict Heart Failure Hospitalization in Patients with Advanced Heart Failure Awaiting Heart Transplantation without Inotropes or Mechanical Circulatory Support

  • Suenaga Tomoyasu
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Fujino Takeo
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University Department of Advanced Cardiopulmonary Failure, Graduate School of Medical Sciences, Kyushu University
  • Hashimoto Toru
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Ishikawa Yusuke
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Shinohara Keisuke
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Matsushima Shouji
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Komman Hitoshi
    Department of Nursing, Kyushu University Hospital
  • Toyosawa Masayo
    Department of Nursing, Kyushu University Hospital
  • Ide Tomomi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
  • Tsutsui Hiroyuki
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University School of Medicine and Graduate School, International University of Health and Welfare
  • Shiose Akira
    Department of Cardiovascular Surgery, Graduate School of Medical Sciences, Kyushu University
  • Kinugawa Shintaro
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University

Description

<p>Although anemia is a common comorbidity that often coexists with heart failure (HF), its clinical impact in patients with advanced HF remains unclear. We investigated the impact of hemoglobin levels on clinical outcomes in patients with advanced HF listed for heart transplantation without intravenous inotropes or mechanical circulatory support.</p><p>We retrospectively reviewed the clinical data of patients listed for heart transplantation at our institute who did not receive intravenous inotropes or mechanical circulatory support between 2011 and 2022. We divided the patients into those with hemoglobin levels lower or higher than the median value and compared the composite of all-cause death and HF hospitalization within 1 year from the listing date.</p><p>We enrolled consecutive 38 HF patients (27 males, 49.1 ± 10.8 years old). The median hemoglobin value at the time of listing for heart transplantation was 12.9 g/dL, and 66.7% of the patients had iron deficiency. None of the patients in either group died within 1 year. The HF hospitalization-free survival rate was significantly lower in the lower hemoglobin group (40.9% versus 81.9% at 1 year, P = 0.020). Multivariate Cox proportional hazards model analysis showed that hemoglobin as a continuous variable was an independent predictor for HF hospitalization (odds ratio 0.70, 95% confidence interval 0.49-0.97, P = 0.030).</p><p>Hemoglobin level at the time of listing for heart transplantation was a predictor of hospitalization in heart-transplant candidates without intravenous inotropes or mechanical circulatory support.</p>

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