LONGITUDINAL EVALUATION OF EFFICACY OF SUBLINGUAL IMMUNOTHERAPY IN PEDIATRIC PERENNIAL ALLERGIC RHINITIS USING LABORATORY EXAMINATIONS AND <i>IN VIVO</i> BIOMARKERS

DOI Web Site PubMed
  • Masuda Sawako
    Department of Otorhinolaryngology, National Hospital Organization Mie National Hospital
  • Usui Satoko
    Department of Otorhinolaryngology, National Hospital Organization Mie National Hospital

Bibliographic Information

Other Title
  • 臨床検査と<i>in vivo</i> biomarkersによる小児通年性アレルギー性鼻炎に対するダニ舌下免疫療法の効果の経時的評価
  • 臨床検査とin vivo biomarkersによる小児通年性アレルギー性鼻炎に対するダニ舌下免疫療法の効果の経時的評価
  • リンショウ ケンサ ト in vivo biomarkers ニ ヨル ショウニ ツウネン セイ アレルギーセイ ビエン ニ タイスル ダニ ゼッカ メンエキ リョウホウ ノ コウカ ノ ケイジテキ ヒョウカ

Search this article

Description

<p>Objective: The purpose of this study was to evaluate the efficacy of sublingual immunotherapy (SLIT) with house dust mite (HDM) on pediatric perennial allergic rhinitis (AR) based on longitudinal assessment of nasal symptoms, laboratory examination, and in vivo biomarkers.</p><p>Method: The subjects included 40 children with perennial AR who had SLIT with HDM for 2 years. Nasal symptoms, medications, skin prick tests, nasal provocation tests, and peripheral blood tests were evaluated before, 6 months, one year and two years after the onset of SLIT.</p><p>Results: Total nasal symptom scores, prick test wheal diameter, and peripheral blood eosinophil count decreased in 6 months. Total nasal symptom scores continued to decrease from 6 months to 2 years. Symptom-medication scores and nasal provocation test responses decreased in 1 year. Symptom-medication scores continued to decline from 1 to 2 years. Medication scores and nasal eosinophilia decreased in 2 years. Serum specific IgE to HDM slightly increased transiently and decreased in 2 years. The severity of symptoms and specific IgE to HDM at the baseline, and changes of symptoms and specific IgE to HDM during the first six months and first one year of SLIT were correlated with improvement in symptom scores over two years of SLUT. TNSS at baseline was correlated with that at second year.</p><p>Conclusion: Longitudinal assessment of symptoms, allergen specific IgE, and in vivo biomarkers showed the effectiveness of SLIT. Symptom scores and allergen specific IgE may also be early predictive factors of SLIT efficacy in children with AR.</p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top