Medication–induced movement disorders―therapy strategy with respect to Parkinson disease and Huntington's disease

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  • Sakakibara Ryuji
    Neurology Clinic Tsudanuma & Dowakai Chiba Hospital
  • Komatsu Naoya
    Neurology Clinic Tsudanuma & Dowakai Chiba Hospital Psychiatry, Dowakai Chiba Hospital
  • Sasahira Natsuyo
    Neurology Clinic Tsudanuma & Dowakai Chiba Hospital Psychiatry, Dowakai Chiba Hospital
  • Shinotoh Hitoshi
    Neurology Clinic Tsudanuma & Dowakai Chiba Hospital Neurology Clinic Chiba

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  • 薬剤誘発性運動疾患―神経疾患からみた治療方策

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<p>We reviewed medication–induced movement disorders (MIMD) with respect to common neurologic movement disorders. MIMD might require blockade of dopaminergic receptors and subsequent receptor supersensitivity. Parkinsonism, dyskinesia, akathisia, catalepsy/catatonia, neuroleptic malignant syndrome and hyperprolactinemia are all conditions that neurologists may encounter. Management requires cessation of antipsychotic medication, changing to brexpiprazole etc. that has less dopaminergic blockade, addition (for hypokinetic form) of possible levodopa, or addition (for hyperkinetic form) of valbenazine etc if necessary. Collaboration of neurologists and psychiatrists is recommended to maximize patients' quality of life.</p>

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