A Case of Superficial Spreading Melanoma on the Back that was Difficult to Differentiate from a Dysplastic Nevus

DOI

Bibliographic Information

Other Title
  • 異型母斑との鑑別に苦慮した背部の表在拡大型黒色腫の 1 例

Search this article

Description

<p>A 55-year-old male presented with a black macule on his back, accompanied by a 6-month history of itching. Malignant melanoma was suspected by his previous doctor, prompting a referral to our department. At the initial visit, a 10×8 mm variegated black macule was observed on the middle back. Biopsy specimens were inconclusive for differentiating between dysplastic nevus and melanoma. Total resection was performed with a 5 mm margin. Imaging studies, including CT and PET-CT, did not detect any distant metastases. A completely excised specimen revealed atypical,spindle-shaped, or pagetoid melanocytes scattered in a pagetoid pattern in the basal and spinous layers. There was a band-like inammatory inltrate and concentric brosis in the supercial dermis below the irregularly elongated and effaced rete ridges. Immunohistochemically, tumor cells were positive for S100-protein, HMB45, MelanA, and PRAME. p16 was partially deleted, and the Ki-67 proliferation index was about 30％. A BRAF V600E mutation was detected. Based on these ndings, a diagnosis of supercial spreading melanoma was established. There was no recurrence or metastasis observed during an 11-month follow-up period. Skin Research, 23 :103-109, 2024 </p>

Journal

  • Hifu no kagaku

    Hifu no kagaku 23 (2), 103-109, 2024

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Keywords

Details 詳細情報について

Report a problem

Back to top