シラノール基被覆処理効果の高い高速液体クロマトグラフィー用光学活性固定相の調製

DOI NDLデジタルコレクション Web Site Web Site 被引用文献1件 参考文献12件

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タイトル別名
  • A new method giving effective coverage of silanol groups for the preparation of chiral stationary phases for HPLC.
  • シラノールキ ヒフク ショリ コウカ ノ タカイ コウソク エキタイ クロマト

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抄録

A new immobilization method for chiral stationary phases on porous silica gel for HPLC was developed. It is known that the hydrosilylation reaction proceed with great difficulty on the silica gel surface. It was, however, found that the reaction proceeds easily when using a highly hydrophobic platinum catalyst. Based on this finding, an immobilization method was developed, in which silylation is carried out first and then the chiral selector is subsequently introduced onto it by the hydrosilylation reaction. This preparation method has the unique feature that it is capable of covering the silanol groups efficiently. Optical resolution of DL-amino acids on the Pirkle-type chiral stationary phase prepared through the proposed method, gave excellent result. The separation factors obtained were the highest ever obtained, especially when the coverage density was very low. Further, the usefulness of this preparation method was tried to be elucidated through simulation by the molecular dynamics method.

収録刊行物

  • 分析化学

    分析化学 44 (4), 289-296, 1995

    公益社団法人 日本分析化学会

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