Novel 3D <i>in vitro</i> model for evaluating vascular permeability

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Other Title
  • 血管透過性評価のための新規3D <i>in vitro</i>微小血管モデル
  • 血管透過性評価のための新規3D in vitro微小血管モデル
  • ケッカン トウカセイ ヒョウカ ノ タメ ノ シンキ 3D in vitro ビショウ ケッカン モデル

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Abstract

Increased vascular permeability is a hallmark of inflammation accompanying tumor progression and diabetic retinopathy. For applying to anti-inflammatory drug testing and screening, we have newly developed an in vitro 3D microvasculature model to evaluate vascular permeability. In this model, we could measure and calculate extravasation pattern of FITCdextran fluorescence and determine endothelial barrier changes in response to thrombin, a known pro-inflammatory protease.

Journal

  • SEISAN KENKYU

    SEISAN KENKYU 67 (3), 255-257, 2015-05-01

    Institute of Industrial Science The University of Tokyo

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