重イオンマイクロビームを用いた細胞１個の狙い撃ち照射

DOI Web Site 参考文献59件
  • 小林 泰彦
    (独)日本原子力研究開発機構　量子ビーム応用研究部門　バイオ応用技術研究ユニット　マイクロビーム細胞照射研究グループ 群馬大学大学院医学系研究科生体機能解析学，群馬大学21世紀 COE プログラム「加速器テクノロジーによる医学・生物学研究」

書誌事項

タイトル別名
  • Single-cell/Single-particle Irradiation Using Heavy-ion Microbeams
  • ジュウイオン マイクロビーム オ モチイタ サイボウ 1コ ノ ネライウチ ショウシャ

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抄録

  Heavy charged particles transfer their energy to biological organisms through high-density ionization along the particle trajectories. The population of cells exposed to a very low dose of heavy-ion beams contains a few cells hit by a particle, while the majority of the cells receive no radiation damage. At somewhat higher doses, some of the cells receive two or more events according to the Poisson distribution of ion injections. This fluctuation of particle trajectories through individual cells makes interpretation of radiological effects of heavy ions difficult. Furthermore, there has recently been an increasing interest in ionizing radiation-induced “bystander effects”, that is, radiation effects transmitted from hit cells to neighboring un-hit cells. Therefore, we have established a single-cell/single-particle irradiation system using a heavy-ion microbeam apparatus at JAEA-Takasaki to study radiobiological processes in hit cells and bystander cells exposed to low dose and low dose-rate high-LET radiations, in ways that cannot be achieved using conventional broad-field exposures.<br>

収録刊行物

  • 真空

    真空 50 (9), 564-568, 2007

    一般社団法人 日本真空学会

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