Single-cell/Single-particle Irradiation Using Heavy-ion Microbeams

  • KOBAYASHI Yasuhiko
    Microbeam Radiation Biology Group, Radiation-Applied Biology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA) Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, The 21st Century Center of Excellence (COE) Program for Biomedical Research Using Accelerator Technology

Bibliographic Information

Other Title
  • 重イオンマイクロビームを用いた細胞1個の狙い撃ち照射
  • ジュウイオン マイクロビーム オ モチイタ サイボウ 1コ ノ ネライウチ ショウシャ

Search this article

Description

Heavy charged particles transfer their energy to biological organisms through high-density ionization along the particle trajectories. The population of cells exposed to a very low dose of heavy-ion beams contains a few cells hit by a particle, while the majority of the cells receive no radiation damage. At somewhat higher doses, some of the cells receive two or more events according to the Poisson distribution of ion injections. This fluctuation of particle trajectories through individual cells makes interpretation of radiological effects of heavy ions difficult. Furthermore, there has recently been an increasing interest in ionizing radiation-induced “bystander effects”, that is, radiation effects transmitted from hit cells to neighboring un-hit cells. Therefore, we have established a single-cell/single-particle irradiation system using a heavy-ion microbeam apparatus at JAEA-Takasaki to study radiobiological processes in hit cells and bystander cells exposed to low dose and low dose-rate high-LET radiations, in ways that cannot be achieved using conventional broad-field exposures.<br>

Journal

  • Shinku

    Shinku 50 (9), 564-568, 2007

    The Vacuum Society of Japan

References(59)*help

See more

Details 詳細情報について

Report a problem

Back to top