Structural Studies of GINS Complex in Eukaryote Replication Machinery

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  • 真核生物の複製制御因子ＧＩＮＳ複合体の構造解析
  • シンカク セイブツ ノ フクセイ セイギョ インシ GINS フクゴウタイ ノ コウゾウ カイセキ

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Abstract

The eukaryotic GINS complex is essential for the establishment of DNA replication forks and replisome progression. We report the crystal structure of the human GINS complex. The heterotetrameric complex adopts a pseudo symmetrical layered structure comprising two heterodimers, creating four subunit-subunit interfaces. The structural and biochemical data suggest that the tetrameric complex ensures a stable platform for the C-terminal domain of Psfl to act as a key interaction interface for other proteins in the replication-initiation process.

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