Protein Crystallography and Structural Biology. Cooperation with Relarted Sciences and Future Plans. Drug Discovery based on Protein Crystallography.

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  • KURIHARA Hiroyuki
    Molecular Design Dept., Molecular Chemistry Research Lab., Yamanouchi Phrmaceutical Co., Ltd.

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  • タンパク質結晶学と構造生物学　周辺科学との協調とその将来　医薬品開発とタンパク質結晶学
  • イヤクヒン カイハツ ト タンパクシツ ケッショウガク

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Abstract

Protein crystallograpy is now a central tool in the drug design process. Using this technique, we can determine atomic resolution structutres for many physiologically important proteins, both in their native state and in complex with a ligand. These data can assist both lead discovery and lead optimization, but at the current time most successful examples have involved the latter, Specific knowledge of the binding site obtained from these structures, enhances the lead optimization process by reducing the number of compounds to be tested. This paper describes the various technologies which are required to make a rational approach successful.

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