Recent Advances in Biology of Crysteinyl Leukotriene
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- AGO Hideo
- RIKEN SPring-8 Center, Structural Biophysics Laboratory
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- MIYANO Masashi
- RIKEN SPring-8 Center, Structural Biophysics Laboratory
Bibliographic Information
- Other Title
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- 構造生物学研究の新展開 ２．基礎研究から応用展開に向けて（ｃ）応用志向型研究 システインロイコトリエン研究の新知見
- システインロイコトリエン研究の新知見
- システインロイコトリエン ケンキュウ ノ シン チケン
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Abstract
Cysteinyl leukotriene has been known to be a major component of SRS-A (Slow Reacting Substance of Anaphylaxis). Inhibitors affecting on its biosynthesis and antagonists of its G-protein coupled receptor are therapeutic agents for acute inflammatory diseases, such as bronchial asthma and rhinitis. Latest findings in pathobiology of asthma suggest that cysteinyl leukotriene would take a key role in not only acute but also chronic inflammation of asthma. The structure basis of biosynthesis of cysteinyl leukotriene was revealed by crystallographic analysis of human membrane protein leukotriene C4 synthase.
Journal
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- Nihon Kessho Gakkaishi
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Nihon Kessho Gakkaishi 52 (1), 69-75, 2010
The Crystallographic Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679063303296
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- NII Article ID
- 10026107914
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- NII Book ID
- AN00188364
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- COI
- 1:CAS:528:DC%2BC3cXltFylsrw%3D
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- ISSN
- 18845576
- 03694585
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- NDL BIB ID
- 10622995
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed