Structural Analysis on the Catalytic Reaction Mechanism of AfcA Fucosidase from Bifidobacterium Bifidum
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- NAGAE Masamichi
- Photon Factory, Institute of Materials Structure Science, KEK
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- TSUCHIYA Atsuko
- Graduate School of Biostudies, Kyoto University
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- YAMAMOTO Kenji
- Graduate School of Biostudies, Kyoto University
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- KATAYAMA Takane
- Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
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- WAKATSUKI Soichi
- Photon Factory, Institute of Materials Structure Science, KEK
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- KATO Ryuichi
- Photon Factory, Institute of Materials Structure Science, KEK
Bibliographic Information
- Other Title
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- ビフィズス菌由来ＡｆｃＡフコシダーゼ触媒ドメインの立体構造解析
- ビフィズスキン ユライ AfcA フコシダーゼ ショクバイ ドメイン ノ リッタイ コウゾウ カイセキ
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Abstract
1, 2-α-L-Fucosidase (AfcA) is an exoglycosidase recently identified from Bifidobacterium bifidum. To elucidate the molecular mechanism of this enzyme, we determined the X-ray crystal structures of the AfcA catalytic domain in unliganded and complexed forms with inhibitor, substrate and products at atomic resolution. A series of the structural and the biochemical analyses provides insight into a novel catalytic mechanism for this enzyme.
Journal
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- Nihon Kessho Gakkaishi
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Nihon Kessho Gakkaishi 50 (2), 138-143, 2008
The Crystallographic Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679063368064
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- NII Article ID
- 10021085666
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- NII Book ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL BIB ID
- 9502112
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed