書誌事項
- タイトル別名
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- Crystal Structure Analysis of Human Dipeptidyl Peptidase IV (DPPIV)
- サイキン ノ ケンキュウ カラ ヒト ユライ ジペプチジルペプチダーゼ IV DPPIV ノ ケッショウ コウゾウ カイセキ
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抄録
Human dipeptidyl peptidase IV (DPPIV) [EC 3.4.14.5] belongs to the prolyl oligopeptidase (POP) family, a member of the serine proteases. The crystal structure of DPPIV was determined at 2.6 Å resolution. The molecule consists of a unique eight-bladed β-propeller domain and a α/β-hydrolase domain. The large“cave”structure, which is thought to control the access of substrate, is found on the side of the β-propeller fold. Furthermore, the crystal structure of DPPIV in complex with diprotin A was determined at 2.2 Å resolution. The structure reveals the molecular interaction mechanism of diprotin A with DPPIV.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 47 (4), 261-267, 2005
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390282679063479168
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- NII論文ID
- 130000800520
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 7473647
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可