Structure and Mechanism of Coenzyme B12 Dependent Enzymes
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- SHIBATA Naoki
- Graduate School of Life Science, University of Hyogo
Bibliographic Information
- Other Title
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- ビタミンB12酵素の構造と機能の研究
- ソウゴウ ホウコク ニホン ケッショウ ガッカイショウ ジュショウ ロンブン ビタミン B12 コウソ ノ コウゾウ ト キノウ ノ ケンキュウ
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Abstract
Coenzyme B12 or adenosylcobalamin, commonly known as Vitamin B12, is one of the most complicated natural organic compounds involved in heteroatom elimination and carbonskeleton rearrangement reactions. Diol dehydratase is an adenosylcobalamin-dependant enzyme that catalyzes conversion from 1, 2-diol compounds to the corresponding aldehydes. Comparison of the structures of the enzyme of substrate-bound and substrate-free forms reveals the activation mechanism of adenosylcobalamin. Structural studies of chiral substrates imply that this enzyme catalyses each enantiomer with different mechanisms in the final step of the reaction.
Journal
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- Nihon Kessho Gakkaishi
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Nihon Kessho Gakkaishi 46 (3), 209-215, 2004
The Crystallographic Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679063702144
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- NII Article ID
- 10013129670
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- NII Book ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL BIB ID
- 7017531
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed