書誌事項
- タイトル別名
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- Biological Significance of a DNA Octaplex and its Splitting Quadruplexes
- サイキン ノ ケンキュウ カラ DNA ノ ヤエ ラセン コウゾウ オヨビ ソノ カイレツ 4ジュウ サ コウゾウ ト ソレラ ノ セイブツガクテキ イギ
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Recent human genome projects have revealed that exons encoding proteins count only a few percents, whereas many kinds of repetitive sequences occupy more than 50 % of genome. Some of the latter are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment of d (gcGA [G] 1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process according to a double Greek-key motif for eight tandem repeats of d (ccGA [G] 4Agg) found in Variable number of tandem repeat (VNTR) immediately adjacent to the human pseudoautosomal telomere. Such a packaging of the repeats could facilitate slippage of a certain VNTR sequence during DNA replication, to induce length polymorphism by increasing or decreasing of the repeats.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 46 (5), 345-351, 2004
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390282679063813120
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- NII論文ID
- 10013740898
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 7138338
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 使用不可