哺乳類フルクトース輸送体GLUT5の構造と分子機構
書誌事項
- タイトル別名
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- Structure and Molecular Mechanism of the Mammalian Fructose Transporter GLUT5
- ホニュウルイ フルクトース ユソウタイ GLUT5 ノ コウゾウ ト ブンシ キコウ
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説明
Excessive consumption of fructose in the Western diet is associated with an increased incidence of metabolic disorders such as obesity and non-alcoholic steatohepatitis. A growing interest is focused on the fructose transporter GLUT5. In this review, we describe crystal structures of the mammalian GLUT5 with its empty binding site exposed to either the extracellular side or intracellular side. By comparing structures in these two different conformational states, we show that the transport is achieved by a combination of global “rocker-switch”-like movement of transmembrane bundles and local asymmetric “gated-pore”-like rearrangement. This structural information is now open for designing novel therapeutic drugs.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 58 (3), 133-138, 2016
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390282679066036864
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- NII論文ID
- 130005159764
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- HANDLE
- 2433/218969
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- NDL書誌ID
- 027502668
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- IRDB
- NDLサーチ
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
