Human Lipoprotein (a) is an Antagonist of Fibrinogen that Binds to the GPIIb (CD41) Protein on Agonist-Stimulated Human Platelets
-
- BARRE D.E.
- University College of Cape Breton
Search this article
Abstract
Human lipoprotein (a) [Lp(a)] binds to the fibrinogen (GPIIb/IIIa) receptor at the CD41 or GPIIb protein on unstimulated platelets. However, this binding has never been examined on stimulated platelets. Different amounts (1-100 mg%) of purified human Lp(a) and fibrinogen (50 mg/100 ml) were incubated with washed human platelets in the presence or absence of an anti-CD41 monoclonal antibody (Mab) directed at the GPIIb protein of the fibrinogen receptor. Mab inhibited binding of Lp(a) and fibrinogen to the GPIIb protein and abolished Lp(a)-induced reduction of platelet aggregation. In a second experiment, washed platelets were incubated with Lp(a) and Mab or with fibrinogen and Mab and then agonist-stimulated, resulting in a reduction of binding of Lp(a) or fibrinogen. It was concluded that Lp(a) must bind to the GPIIb site to reduce platelet aggregation which apparently occurs via a competition of Lp(a) and fibrinogen for the same site on the IIb portion of the fibrinogen binding site on agonist-stimulated human platelets.<br>
Journal
-
- Journal of Oleo Science
-
Journal of Oleo Science 53 (6), 305-308, 2004
Japan Oil Chemists' Society
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679067444224
-
- NII Article ID
- 10012946091
-
- NII Book ID
- AA11503337
-
- ISSN
- 13473352
- 13458957
-
- NDL BIB ID
- 6943093
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed