Evaluation of the Hardness of Lipid Bilayer Membranes of Liposomes by the Ultrasound Attenuation Method
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- MORIYAMA Eiji
- Faculty of Engineering, Toin University of Yokohama
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- SAITO Tomohiro
- Faculty of Engineering, Toin University of Yokohama
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- TOKUOKA Yoshikazu
- Biomedical Engineering Center, Toin University of Yokohama
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- TAKEUCHI Shinichi
- Faculty of Engineering, Toin University of Yokohama
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- KAWASHIMA Norimichi
- Faculty of Engineering, Toin University of Yokohama Biomedical Engineering Center, Toin University of Yokohama
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抄録
We attempted to evaluate the hardness of lipid bilayer membranes of liposomes by an ultrasound attenuation method and compared the results with these obtained by a representative fluorescence probe method using pyrene. We used multilamellar vesicles type of liposomes prepared by Bangham’s method. In the ultrasound attenuation method, the measurement of the ultrasonic attenuation constant of liposomes dispersions indicated that the hardness of the bilayer membranes of the liposomes increased with the increasing cholesterol concentration and the decreasing temperature. This tendency was identical with that found in the results obtained by the fluorescence probe method using pyrene. Therefore, we consider that the ultrasound attenuation method is useful for estimating the hardness of lipid bilayer membranes of multilamellar vesicles type of liposomes.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 52 (8), 433-437, 2003
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679067650048
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- NII論文ID
- 130000060489
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- NII書誌ID
- AA11503337
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- COI
- 1:CAS:528:DC%2BD3sXlvFSgs78%3D
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 6606907
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可