Conjugated Linoleic Acid Reduces Hepatic Microsomal Triacylglycerol Transfer Protein Activity and Hepatic Triacylglycerol Mass in Obese Rats.

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  • WANG Yu-Ming
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
  • RAHMAN Shaikh Mizanoor
    Department of Biochemistry, University of Wisconsin-Madison
  • NAGAO Koji
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
  • HAN Seo-Young
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
  • BUANG Yohanes
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
  • CHA Jae-Young
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University
  • YANAGITA Teruyoshi
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University

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Abstract

Conjugated linoleic acid (CLA) is known to modulate lipid and lipoprotein metabolism. We examined the effects of dietary CLA (1 and 2%) on hepatic microsomal triacylglycerol transfer protein (MTP) activity, known to be essential for the assembly/secretion of the apolipoprotein B-containing lipoproteins, and lipid concentrations of liver and plasma in OLETF obese rats. A significant reduction in hepatic MTP activity in CLA-fed rats in comparison to rats fed a linoleic acid (LA) diet was noted. Hepatic and serum triacylglycerol (TAG) concentrations were lowered in the CLA groups as compared to the control LA group. Decreased serum insulin and leptin levels were seen in the CLA groups. These results indicate that dietary CLA reduces both hepatic MTP activity and TAG content, and therefore reduces hepatic lipoprotein assembly and secretion.<br>

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