Evaluation of Toxicity of Lauryl-imino-dicarboxylate by Means of Cytotoxicity Test

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  • 細胞毒性試験によるラウリルイミノジカルボン酸塩の毒性に関する評価
  • サイボウ ドクセイ シケン ニヨル ラウリルイミノジカルボンサンエン ノ ドク

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Abstract

Lauryl-imino-diacetate (LIDA) is an amphoteric surfactant useful as a base for human body detergents. Owing to its stable dibasic acid moiety, application is possible over a wide pH range.<BR>In this study, assessment was made of the cytotoxicity of LIDA and other surfactants by NR, WST-1, leakage in LDH and hemolysis. All those methods are alternatives to animal experiments such as the Draize test. Membrane fluidity change of human epidermal keratinocytes by surfactants was detected by polarized light measurement of probe molecules in the cell membrane.<BR>LIDA and lauryl-imino-dipropionate (LIDP) showed low cytotoxicity in all cases. Membrane fluidity scarcely changed for LIDA and LIDP, whereas for lauryl-amino-acetate (LAA) and lauryl-amino-propionate (LAP), change was quite clear. The change in fluidity by LAA and LAP may have been related to the induction of cytotoxicity.

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