Microbial Transformation of Isopimpinellin by Glomerella cingulata
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- Marumoto Shinsuke
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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- Miyazawa Mitsuo
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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Abstract
Microbial transformation studies conducted on isopimpinellin (1) by the fungus Glomerella cingulata have revealed that 1 was metabolized to give the corresponding reduced acid, 5,8-dimethoxy-6,7-furano-hydrocoumaric acid (2). The structure of metabolite 2 was elucidated by high-resolution mass spectrometry (HR-MS), extensive NMR techniques, including 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC) and heteonuclear multiple bond coherence (HMBC). The biotransformed product 2 showed weak a in vitro β-secretase (BACE1) inhibitory effect.
Journal
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- Journal of Oleo Science
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Journal of Oleo Science 60 (11), 575-578, 2011
Japan Oil Chemists' Society
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Details 詳細情報について
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- CRID
- 1390282679068359936
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- NII Article ID
- 130001373807
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- NII Book ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL BIB ID
- 11279292
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed