Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial.

HAYAMIZU Kohsuke, ISHII Yuri, KANEKO Izuru, SHEN Manzhen, SAKAGUCHI Hiroyuki, OKUHARA Yasuhide, SHIGEMATSU Norihiro, MIYAZAKI Shigeru, SHIMASAKI Hiroyuki

doi:10.5650/jos.50.805

Bibliographic Information

Other Title

ガルシニアエキス長期投与による人の内臓脂肪蓄積への影響　　プラセボ二重盲検比較試験（原標題は英語）
Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial〔和文〕
Effects of Long term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans A Placebo controlled Double Blind Trial ワブン

Search this article

Description

(−)-Hydroxycitric acid (HCA), an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia inhibits ATP-citrate lyase and is used for anti-obesity treatment. This study was conducted to examine the long-term effects of G. cambogia extracts on body fat accumulation in humans who are preobese or obese class 1 (body mass index from 25 to 35 kg/m²). A total of 40 subjects were randomized to either a G. cambogia (n=20, 1000 mg of HCA per day) or a placebo (n=20) group. The treatment period was 8 weeks. Each was subjected to computed tomography (CT) scan at the umbilical level before and after the treatment period, and blood samples taken to measure the clinical laboratory data every 4 weeks. As for a higher visceral fat area (VFA) in the subjects (with an initial VFA over 90 cm²), both the VFA and VFA/SFA (subcutaneous fat area) ratio in the G. cambogia group significantly decreased, compared to the placebo group (p<0.01 and p<0.05, respectively). Triacylglycerol was also reduced significantly in higher VFA subjects in the G. cambogia group, compared to the initial levels (p=0.05), but there were no significant difference between the groups in loss of body weight and the waist-hip ratio. No adverse effect was observed through out the test period. In conclusion, G. cambogia extract is useful for reducing body fat accumulation, especially visceral fat accumulation.

Journal

Journal of Oleo Science

Journal of Oleo Science 50 (10), 805-812, 2001

Japan Oil Chemists' Society

Keywords

Details 詳細情報について

Export

Report a problem