Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial.
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- HAYAMIZU Kohsuke
- Central laboratory, FANCL Corporation
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- ISHII Yuri
- Central laboratory, FANCL Corporation
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- KANEKO Izuru
- Central laboratory, FANCL Corporation
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- SHEN Manzhen
- Central laboratory, FANCL Corporation
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- SAKAGUCHI Hiroyuki
- Central laboratory, FANCL Corporation
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- OKUHARA Yasuhide
- Central laboratory, FANCL Corporation
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- SHIGEMATSU Norihiro
- Central laboratory, FANCL Corporation
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- MIYAZAKI Shigeru
- Department of Internal Medicine, Tokyo Teishin Hospital
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- SHIMASAKI Hiroyuki
- Department of Biochemistry, Teikyo University School of Medicine
Bibliographic Information
- Other Title
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- ガルシニアエキス長期投与による人の内臓脂肪蓄積への影響 プラセボ二重盲検比較試験(原標題は英語)
- Effects of Long-term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans: A Placebo-controlled Double Blind Trial〔和文〕
- Effects of Long term Administration of Garcinia cambogia extract on Visceral Fat Accumulation in Humans A Placebo controlled Double Blind Trial ワブン
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Abstract
(−)-Hydroxycitric acid (HCA), an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia inhibits ATP-citrate lyase and is used for anti-obesity treatment. This study was conducted to examine the long-term effects of G. cambogia extracts on body fat accumulation in humans who are preobese or obese class 1 (body mass index from 25 to 35 kg/m2). A total of 40 subjects were randomized to either a G. cambogia (n=20, 1000 mg of HCA per day) or a placebo (n=20) group. The treatment period was 8 weeks. Each was subjected to computed tomography (CT) scan at the umbilical level before and after the treatment period, and blood samples taken to measure the clinical laboratory data every 4 weeks. As for a higher visceral fat area (VFA) in the subjects (with an initial VFA over 90 cm2), both the VFA and VFA/SFA (subcutaneous fat area) ratio in the G. cambogia group significantly decreased, compared to the placebo group (p<0.01 and p<0.05, respectively). Triacylglycerol was also reduced significantly in higher VFA subjects in the G. cambogia group, compared to the initial levels (p=0.05), but there were no significant difference between the groups in loss of body weight and the waist-hip ratio. No adverse effect was observed through out the test period. In conclusion, G. cambogia extract is useful for reducing body fat accumulation, especially visceral fat accumulation.
Journal
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- Journal of Oleo Science
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Journal of Oleo Science 50 (10), 805-812, 2001
Japan Oil Chemists' Society
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Keywords
Details
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- CRID
- 1390282679068462208
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- NII Article ID
- 10006943575
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- NII Book ID
- AA11503337
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- COI
- 1:CAS:528:DC%2BD3MXntFWnur8%3D
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- ISSN
- 13473352
- 13458957
- http://id.crossref.org/issn/13458957
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- NDL BIB ID
- 5919056
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed