Isolation and Synthesis of Cosmetic Substances from African Dietary Leaves, Celosia argentea L. for Skin Depigmentation.
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- SAWABE Akiyoshi
- Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
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- NOMURA Masato
- Department of Chemistry and Environmental Technology, Faculty of Engineering, Kinki University
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- FUJIHARA Yoshihito
- Department of Chemistry and Environmental Technology, Faculty of Engineering, Kinki University
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- TADA Takahiro
- Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.
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- HATTORI Fumihiro
- Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.
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- SHIOHARA Satoko
- Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.
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- SHIMOMURA Kenji
- Natural Material Group, Research & Development Division, Mikimoto Pharmaceutical Co., Ltd.
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- MATSUBARA Yoshiharu
- Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
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- KOMEMUSHI Sadao
- Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
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- OKAMOTO Tadashi
- Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
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- KAWAMURA Saburou
- Department of Agricultural Chemistry, Faculty of Agriculture, Kinki University
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抄録
Six compounds were isolated from the leaves of Celosia argentea L.. Tyrosinase inhibitory and superoxide scavenging activity of the compounds was examined so as to obtain a skin depigmentation agent for cosmetic application. Eugenyl O-β-D-glucopyranoside (citrusin C, 1) showed strong tyrosinase inhibitory activity. Two-step inhibitory effects of successive tyrosine and DOPA oxidation for tyrosinase were stronger compared to arbutin used commercially at present (47.20% inhibition of tyrosine oxidation and 87.93%, DOPA oxidation, compared to 63.00% for tyrosine and 7.70% for DOPA oxidation in the case of arbutin). Moreover, we succeed in providing compound 1 abundantly in the synthetic study which used acetobromo-α-D-glucose and Sn(OTf)2.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 51 (3), 203-206, 2002
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679068496896
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- NII論文ID
- 10008009780
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 6066841
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可