α-glucosidase inhibitor from Bergenia ligulata

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タイトル別名
  • .ALPHA.-Glucosidase Inhibitor from Bergenia ligulata
  • a glucosidase inhibitor from Bergenia ligulata

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抄録

Inhibitory compound of α-glucosidase activity, (+)-afzelechin (1), was isolated from rhizomes of Bergenia ligulata. The structure was identified by IR, EI-MS, 1H and 13C NMR spectroscopy. The ID50 (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-afzelechin tetraacetate (2), (+)-5,7,4’-trimethoxyafzelechin (3), (+)-tetramethoxyafzelechin (4), and (+)-3-acetyl-5,7,4’-trimethoxyafzelechin (5) as the derivatives of compound 1 were evaluated as well.<br>

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