.ALPHA.-Glucosidase Inhibitor from Bergenia ligulata
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- Saijyo Junichi
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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- Suzuki Yousuke
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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- Okuno Yoshiharu
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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- Yamaki Hidehiko
- Koei Kogyo Co., Ltd.
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- Suzuki Takuya
- Koei Kogyo Co., Ltd.
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- Miyazawa Mitsuo
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
Bibliographic Information
- Other Title
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- α-glucosidase inhibitor from Bergenia ligulata
- a glucosidase inhibitor from Bergenia ligulata
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Abstract
Inhibitory compound of α-glucosidase activity, (+)-afzelechin (1), was isolated from rhizomes of Bergenia ligulata. The structure was identified by IR, EI-MS, 1H and 13C NMR spectroscopy. The ID50 (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-afzelechin tetraacetate (2), (+)-5,7,4’-trimethoxyafzelechin (3), (+)-tetramethoxyafzelechin (4), and (+)-3-acetyl-5,7,4’-trimethoxyafzelechin (5) as the derivatives of compound 1 were evaluated as well.<br>
Journal
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- Journal of Oleo Science
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Journal of Oleo Science 57 (8), 431-435, 2008
Japan Oil Chemists' Society
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Details 詳細情報について
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- CRID
- 1390282679068856576
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- NII Article ID
- 130000055379
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- NII Book ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL BIB ID
- 9579324
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed