Synthesis and Antibacterial Activity of Quaternary Ammonium Salt-Type Antibacterial Agents with a Phosphate Group

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  • Ohta Yumi
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science
  • Kondo Yukishige
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science Division of Colloid and Interface Science, Research Institute for Science and Technology, Tokyo University of Science
  • Kawada Kazuo
    Department of Chemistry, School of Science, Kitasato University
  • Teranaka Toshio
    Department of Oral Medicine, Division of Restorative Dentistry, Kanagawa Dental College
  • Yoshino Norio
    Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science Division of Colloid and Interface Science, Research Institute for Science and Technology, Tokyo University of Science

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Quaternary ammonium salts are frequently used as antibacterial agent that disrupts cell membrane through the binding of their ammonium cations to anionic sites in the outer layer tissue of bacteria. This article describes the synthesis of quaternary ammonium salt-type antibacterial agents with a phosphate group that strongly binds to hydroxyapatite and bromide ion as counterion. Evaluation of the antibacterial activity of the synthesized compounds in terms of minimum inhibitory concentration (MIC test) showed that the compounds exhibit an excellent antibacterial activity on a variety of bacteria including Gram-positive and Gram-negative bacteria, yeast, and fungi.<br>

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