Ingestion of Chlorella Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects
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- Miyazawa Taiki
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Nakagawa Kiyotaka
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Takekoshi Hideo
- Production & Development Department, Sun Chlorella Co., Ltd.
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- Higuchi Ohki
- Biodynamic Plant Institute Co., Ltd.
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- Kato Shunji
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Kondo Momoko
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Kimura Fumiko
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- Miyazawa Teruo
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
書誌事項
- タイトル別名
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- Ingestion of <i>Chlorella</i> Reduced the Oxidation of Erythrocyte Membrane Lipids in Senior Japanese Subjects
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抄録
Accumulation of phospholipid hydroperoxide (PLOOH) in erythrocyte membranes is an abnormality found in patients with senile dementia, including those with Alzheimer’s disease. In our previous studies, dietary xanthophylls (polar carotenoids such as lutein) were hypothesized to inhibit lipid peroxidation. In the present study, we conducted a randomized, double-blind, placebo-controlled human trial to assess the impact for a total of 2 months Chlorella supplementation (8 g Chlorella/day/person; equivalent to 22.9 mg lutein/day/person) on PLOOH and carotenoid concentrations in erythrocytes as well as plasma of 12 normal senior subjects. After 1 or 2 months of treatment, erythrocytes and plasma lutein concentrations increased in the Chlorella group but not in the placebo group. In the Chlorella-supplemented group, erythrocyte PLOOH concentrations after a total of 2 months of treatment were lower than the concentrations before supplementation. These results suggest that Chlorella ingestion improved erythrocyte antioxidant status and lowered PLOOH concentrations. These reductions might contribute to maintaining the normal function of erythrocytes and prevent the development of senile dementia.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 62 (11), 873-881, 2013
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679068876416
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- NII論文ID
- 130004435997
- 40019836554
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- NII書誌ID
- AA11503337
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- COI
- 1:STN:280:DC%2BC2c7jvFWjsw%3D%3D
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 024947418
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- PubMed
- 24200934
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可