Effect of dietary n-6/n-3 ratio on liver n-6/n-3 ratio and peroxisomal β-oxidation activity in rats
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- Takeuchi Hiroyuki
- Central Research Laboratory, The Nisshin Oillio Group
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- Kojima Keiichi
- Central Research Laboratory, The Nisshin Oillio Group
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- Sekine Seiji
- Central Research Laboratory, The Nisshin Oillio Group
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- Murano Yoshihiro
- Central Research Laboratory, The Nisshin Oillio Group
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- Aoyama Toshiaki
- Central Research Laboratory, The Nisshin Oillio Group
書誌事項
- タイトル別名
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- Effect of Dietary n-6/n-3 Ratio on Liver n-6/n-3 Ratio and Peroxisomal .BETA.-Oxidation Activity in Rats
- Effect of dietary n 6 n 3 ratio on liver n 6 n 3 ratio and peroxisomal v oxidation activity in rats
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説明
The optimal dietary n-6/n-3 ratio has not been fully elucidated. To investigate the influence of the dietary n-6/n-3 ratio on this ratio in the body and on liver β-oxidation peroxisomal activity, rats were fed diets containing fat at an n-6/n-3 ratio of 1 to 16 for 4 weeks. To investigate whether elevation of the liver peroxisomal β-oxidation activity increases the n-6/n-3 ratio in the body, rats were fed a diet containing a peroxisome-activating agent, bezafibrate, for 2 weeks, and its influence on the liver n-6/n-3 ratio was examined. The slope of the regression line between the dietary and liver total lipid n-6/n-3 ratios was significantly smaller when the dietary n-6/n-3 ratio was 4 or greater than when it was smaller than 4. Peroxisomal β-oxidation and acyl CoA oxidase activities were significantly lower in rats fed a diet with an n-6/n-3 ratio of 16 than in those fed a diet with a ratio of 1. The peroxisomal β-oxidation activity in the bezafibrate-supplemented group was significantly higher than that in the control group. The serum and liver total lipid n-6/n-3 ratios were significantly higher in the 0.015% bezafibrate-supplemented group than in the control group. These findings suggest that the liver n-6/n-3 ratio might be controlled via peroxisomal β-oxidation in rats.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 57 (12), 649-657, 2008
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679069185152
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- NII論文ID
- 130000435863
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 9708837
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可