.ALPHA.-Tocopherol Transfer Protein and Familial Vitamin E Deficiency.

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  • ARAI Hiroyuki
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo
  • ARITA Makoto
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo
  • INOUE Keizo
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo

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  • ビタミンＥ輸送タンパク質と先天性ビタミンＥ欠乏症
  • ビタミン E ユソウ タンパクシツ ト センテンセイ ビタミン E ケツボウシ

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Abstract

α-tocopherol, the most biologically active form of vitamin E, is a lipid soluble antioxidant that protects membranes from oxidative stresses. Vitamin E occurs in nature in eight different forms, but animal body is enriched in α-tocopherol compared with other forms. Studies on the transport of vitamin E in animals and man suggest that the liver plays a key role in the preferential retention, and subsequent distribution of α-tocopherol to tissues, but little is known about the mechanism. We have purified α-tocopherol transfer protein (α TTP) from rat liver and cloned its cDNA. α TTP specifically binds α-tocopherol and enhances its transfer between membranes. Furthermore, we have identified α TTP is abnormal in the patients with familial isolated vitamin E deficiency. In conclusion, α TTP plays a key role in discrimination of tocopherols as well as determination of serum vitamin E concentrations.

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