Safety of Garcinia cambogia Extract in Healthy Volunteers: High-Dose Administration Study II
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- ISHII Yuri
- Central Research Laboratory, FANCL Corporation
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- KANEKO Izuru
- Central Research Laboratory, FANCL Corporation
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- SHEN Manzhen
- Central Research Laboratory, FANCL Corporation
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- HAYAMIZU Kohsuke
- Central Research Laboratory, FANCL Corporation
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- SHIGEMATSU Norihiro
- Central Research Laboratory, FANCL Corporation
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- TOMI Hironori
- Food Development Laboratories, Nippon Shinyaku Corporation
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- YOSHINO Gen
- Department of Laboratory Medicine, Toho University School
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- SHIMASAKI Hiroyuki
- Department of Biochemistry, Teikyo University of Medicine
Bibliographic Information
- Other Title
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- Safety of Garcinia cambogia Extract in Healthy Volunteers: High-Dose Administration Study 2
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Abstract
The purpose of this study was to review the safety of long-term excessive ingestion of Garcinia extract. For 12 weeks, a dosage of 5000 mg Garcinia extract powder (3000 mg/day as (-)-hydroxycitric acid [(-)-HCA]) was administered to healthy subjects (men 24, women 24). Hematology, hemobiochemistry, endocrinology and urinalysis were carried out every four weeks. Endocrinologically, serum inhibin B increased in men (P<0.05), from 162.1 ± 46.2 pg/mL to 186.7 ± 61.6 pg/mL. In addition, Follicle Stimulating Hormone (FSH) increased (P<0.05), from 4.68 ± 2.65 mIU/mL to 5.18 ± 2.75 mIU/mL. It is hard to conceive the changes had a testiculus influence, because the changes were very slight and no reciprocal relationships existed between them. In women, no significant change of sex hormone was noted and no influence on menstrual cycles was observed. Neither remarkable changes in hematology, hemobiochemistry and urinalysis nor adverse events were observed. These findings support the safety for humans of long-term excessive administration of Garcinia extract (3000 mg/day as HCA, 12 weeks) was high.<br>
Journal
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- Journal of Oleo Science
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Journal of Oleo Science 52 (12), 663-671, 2003
Japan Oil Chemists' Society
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Details 詳細情報について
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- CRID
- 1390282679069616896
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- NII Article ID
- 10012549739
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- NII Book ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL BIB ID
- 6750643
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed