Effect of Peucedanum japonicum Thunb on the Expression of Obesity-Related Genes in Mice on a High-Fat Diet
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- Nukitrangsan Natthanan
- United Graduate School of Agricultural Sciences, Kagoshima University Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus
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- Okabe Takafumi
- Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus
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- Toda Takayoshi
- Department of Clinical Labolatory Medicine, School of Medicine, University of the Ryukyu Hospital
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- Inafuku Masashi
- Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus
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- Iwasaki Hironori
- Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus
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- Yanagita Teruyoshi
- Laboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University
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- Oku Hirosuke
- Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus
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説明
The present study describes the effect of Peucedanum japonicum Thunb (PJT) intake on the expression of obesity-related genes in mice fed a high-fat diet. To explore the mechanism underlying the effect of PJT, This study focused on the expression of genes, especially those related to obesity and metabolism syndrome, in the liver and adipose tissues. In agreement with our previous observations, intake of 10 % PJT for 4 weeks significantly reduced serum triglyceride (TG), leptin, abdominal fat, and adipocyte size. PJT also significantly increased fecal excretion of TG, decreased that of bile acid, and tended to increase the fecal excretion of total cholesterol. Microarray analysis was used to monitor changes in 324 metabolic syndrome-related genes in the liver. Statistically significant upregulation of PPP1R10, RORC, and PBEF1 genes and downregulation of DUSP1, INSIG2, and SERPINA12 genes were noted and confirmed by real-time RT-PCR. These changes were indicative of increased fatty acid oxidation in the maintenance of lipid homeostasis and insulin sensitivity in the livers of PJT-fed mice. PJT increased the expression of PPARγ, FXRα, DGAT1, and ATGL genes, suggesting an enhancement of adipocyte differentiation and normalization of functionality of adipose tissue.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 60 (10), 527-536, 2011
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679069890176
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- NII論文ID
- 130001008506
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 11245270
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可