DSPC/DLPC Mixed Films Supported on Silica: A QCM-D and Friction Force Study
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- Oguchi Takakuni
- Department of Pure and Applied Chemistry in Faculty of Science and Technology and Research Institute for Science and Technology, Tokyo University of Science
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- Sakai Kenichi
- Department of Pure and Applied Chemistry in Faculty of Science and Technology and Research Institute for Science and Technology, Tokyo University of Science
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- Sakai Hideki
- Department of Pure and Applied Chemistry in Faculty of Science and Technology and Research Institute for Science and Technology, Tokyo University of Science
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- Abe Masahiko
- Department of Pure and Applied Chemistry in Faculty of Science and Technology and Research Institute for Science and Technology, Tokyo University of Science
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The membrane properties of phospholipid mixtures supported on silica were studied by means of a quartz crystal microbalance with dissipation monitoring (QCM-D) technique, in situ soft-contact atomic force microscopy (AFM), and friction force microscopy (FFM). The phospholipids used in this study were di-stearoylphosphatidylcholine (DSPC) and dilauroylphosphatidylcholine (DLPC). The phospholipid films were prepared by a vesicle-fusion method, in which DSPC/DLPC mixed liposomes dispersed in an aqueous medium are adsorbed on silica and their structure is transformed into a bilayer on the substrate. The changes in QCM-D (frequency and dissipation) and friction responses of DSPC single systems (gel state at 25°C) are relatively large compared with those of DLPC single systems (liquid-crystalline state at 25°C) and those of mixed DSPC/DLPC systems. This suggests that (i) the gel-state DSPC liposomes are somewhat flattened on the silica, by keeping their solid-like molecular rigidity, whereas (ii) both the liquid-crystalline DLPC and mixed liposomes experience instantaneous structural transformation at the silica/water interface and form a normally flattened bilayer on the substrate. The friction force response is dependent on the phase state of the phospholipids, and the liquid-crystalline DLPC has a more significant impact on the overall membrane properties (i.e., the degree of swelling and the friction response on the surface) than does the gel-state DSPC.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 60 (4), 177-183, 2011
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679070144128
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- NII論文ID
- 130000668009
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 11004818
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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