Sister Chromatid Exchange and Chromosome Aberrations Analyses for a New 8-dminoquinoline Derivative After in vivo Exposure in Mice.

Giri Ashok Kumar, Khan Kaleem Ahmad, Srivastava Sushil Kumar, Sethi Nirmal

doi:10.1508/cytologia.57.331

Sister Chromatid Exchange and Chromosome Aberrations Analyses for a New 8-dminoquinoline Derivative After in vivo Exposure in Mice.

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Giri Ashok Kumar

Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace
Khan Kaleem Ahmad

Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace
Srivastava Sushil Kumar

Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace
Sethi Nirmal

Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace

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説明

A new antimalarial compound 8-aminoquinoline derivative, N¹-(3-acetyl-4-5-dihydro-2-furanyl)-N⁴-(6-methoxy-8-quinolinyl), 1, 4-pentanediamine, Central Drug Research Institute code No. 80/53, has been evaluated for the in vivo genotoxicity assay as measured by the sister chromatid exchange and chromosome aberrations in bone marrow cells of mice. The trend tests for the evidence of dose response effects for both SCE and CA were negative. No significant increase in SCE or CA were observed for this compound when compared with respective negative controls. Thus, the present study indicates that the antimalarial compound 80/53 was not genotoxic in vivo in bone marrow cells of mice.