Sister Chromatid Exchange and Chromosome Aberrations Analyses for a New 8-dminoquinoline Derivative After in vivo Exposure in Mice.

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  • Giri Ashok Kumar
    Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace
  • Khan Kaleem Ahmad
    Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace
  • Srivastava Sushil Kumar
    Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace
  • Sethi Nirmal
    Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace

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Description

A new antimalarial compound 8-aminoquinoline derivative, N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl), 1, 4-pentanediamine, Central Drug Research Institute code No. 80/53, has been evaluated for the in vivo genotoxicity assay as measured by the sister chromatid exchange and chromosome aberrations in bone marrow cells of mice. The trend tests for the evidence of dose response effects for both SCE and CA were negative. No significant increase in SCE or CA were observed for this compound when compared with respective negative controls. Thus, the present study indicates that the antimalarial compound 80/53 was not genotoxic in vivo in bone marrow cells of mice.

Journal

  • CYTOLOGIA

    CYTOLOGIA 57 (3), 331-334, 1992

    Japan Mendel Society, International Society of Cytology

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