動脈壁コレステロール代謝に及ぼす運動トレーニングの影響

安部 孝, 坂元 晃史, 浅見 俊雄, 東 悳彦, 広田 公一

doi:10.5432/jjpehss.kj00003391531

動脈壁コレステロール代謝に及ぼす運動トレーニングの影響

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安部孝

東京大学教養学部保健体育科
坂元晃史

昭和大学薬学部生理化学教室
浅見俊雄

東京大学教養学部保健体育科
東悳彦

筑波大学基礎医学系
広田公一

日本体育大学体育生理研究室

書誌事項

タイトル別名

Effects of exercise training on cholesterol metabolism in rat arterial wall
ドウミャクヘキコレステロールタイシャニオヨボスウンドウトレーニング

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説明

In order to examine the effects of exercise training on cholesterol metabolism of arterial wall, male Wistar rats were randomly divided into a sedentary control (n=35) or an exercise group (n=28). The exercise consisted of tradmill running 60 min/day for 5 weeks. After 5 weeks, the rats were injected 2μCi of C-mevalonate per 100g b.w. into peritoneal cavities, and the incorporation of radioactivity into cholesterol of arterial wall was exaimined at various times after the injection. The exercised rats showed a significantly lower of total cholesterol in aortic tissue than did the controls. The incorporation of mevalonate into aorta cholesterol in the exercise trained rats was significantly higher compared with those of the sedentary control group. Since serum lipoprotein uptake in rat arterial wall was increased by exercise training, the decrease in aota cholesterol level observed following exercise seems to be caused by rapid catabolism of cholesterol in the aortic cell.