The Preparation of <i>N</i>-Protected Amino Alcohols and <i>N</i>-Protected Peptide Alcohol by Reduction of the Corresponding Esters with Sodium Borohydride. An Improved Procedure Involving a Slow Addition of a Small Amount of Methanol

DOI DOI PDF 被引用文献3件 参考文献12件 オープンアクセス
  • Soai Kenso
    Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
  • Oyamada Hidekazu
    Department of Applied Chemistry, Faculty of Science, Science University of Tokyo
  • Takase Masako
    Department of Applied Chemistry, Faculty of Science, Science University of Tokyo

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  • The preparation of N-protected amino alcohols and N-protected peptide alcohol by reduction of the corresponding esters with sodium borohydride. An improved procedure involving a slow addition of a small amount of methanol.

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説明

Esters of N-protected amino acids and an N-protected peptide were reduced selectively to the corresponding alcohols in high yields using lesser amounts of sodium borohydride than does the conventional method by the slow addition of methanol to the mixture of ester and NaBH4 in t-butyl alcohol or tetrahydrofuran at 50°C.

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