Synthesis of shikalkin (.+-.shikonin) and related compounds.
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- Terada Akira
- Department of Chemistry, Kyushu Institute of Technology
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- Tanoue Yasuhiro
- Department of Chemistry, Kyushu Institute of Technology
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- Hatada Akira
- Department of Chemistry, Kyushu Institute of Technology
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- Sakamoto Hiroshi
- Department of Chemistry, Kyushu Institute of Technology
Bibliographic Information
- Other Title
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- Synthesis of Shikalkin (±Shikonin) and Related Compounds
Abstract
The key intermediate, 2-formyl-1,4,5,8-tetramethoxynaphthalene, was prepared through 1,4,5,8-tetramethoxynaphthalene, which was obtained from 1,5-naphthalenediol via three steps or from naphthazarin via one step. A total synthesis of shikalkin and dihydroshikalkin have been accomplished with this aldehyde via a side-chain introductions with Grignard reactions and the following demethylations.
Journal
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 60 (1), 205-213, 1987
The Chemical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679105515904
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- NII Article ID
- 130001982511
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- ISSN
- 13480634
- 00092673
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed