The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from <i>Streptomyces</i> sp. and Their Related Substances
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- Shimbashi Akiko
- Department of Chemistry, Faculty of Science and Technology, Keio University
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- Tsuchiya Ayako
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
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- Imoto Masaya
- Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
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- Nishiyama Shigeru
- Department of Chemistry, Faculty of Science and Technology, Keio University
書誌事項
- タイトル別名
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- The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp. and Their Related Substances
- Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp and Their Related Substances
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抄録
The total synthesis of a novel pyranonaphthoquinone (2) having Cdc25A phosphatase inhibitory activity is achieved. The key step in this synthetic pathway is the intramolecular Michael addition for construction of the pyran ring system. The inhibitory activity of several derivatives, readily obtained from synthetic intermediates of 2, is assessed. The resulting data indicates that the pyran ring moiety is not a crucial factor for the activity.
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 77 (10), 1925-1930, 2004
公益社団法人 日本化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679105862400
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- NII論文ID
- 130004151575
- 10013737952
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- NII書誌ID
- AA00580132
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- ISSN
- 13480634
- 00092673
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- NDL書誌ID
- 7111906
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可