Studies of the Reissert-Kaufmann-type Reaction of 4-Nitropyridine <I>N</I>-Oxide and Its Homologues

DOI PDF 被引用文献2件 参考文献9件 オープンアクセス

書誌事項

公開日
1970
DOI
  • 10.1246/bcsj.43.3210
公開者
公益社団法人 日本化学会

この論文をさがす

説明

The Reissert-Kaufmann-type reaction of substituted N-methoxy-4-nitropyridinium methylsulfates gave the corresponding 2-cyano-4-nitropyridines in satisfactory yields. When 3-methyl-4-nitropyridine N-oxide was used as the starting material, a cyano group was introduced not into the 6-position, but into the 2-position. This preference may be explained by proposing a hyperconjugation effect of the 3-methyl group. The resulting nitriles were quantitatively hydrolyzed to the corresponding 4-nitropicolinic acids. These reactions provided a new route for the preparation of nitropyridinecarboxylic acids from pyridine homologues. Further, some nucleophilic substitution reactions of the products were carried out.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (9)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ