NMR study of spontaneous degradation of penicillin G in aqueous solution.
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- Mitsumori Fumiyuki
- Department of Chemistry, Faculty of Science, The University of Tokyo
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- Arata Yoji
- Department of Chemistry, Faculty of Science, The University of Tokyo
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- Fujiwara Shizuo
- Department of Chemistry, Faculty of Science, The University of Tokyo
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- Muranaka Masaharu
- School of Medicine, The University of Tokyo
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- Horiuchi Yoshihiko
- School of Medicine, The University of Tokyo
Description
The spontaneous degradation of penicillin G in aqueous solution has been studied using NMR and thin layer chromatography. Correlation NMR spectroscopy was used to follow products which appear at the early stage of degradation. It has been found that in 0.3 M phosphate buffer (pH 7.0, 30 °C) a successive first order degradation<BR>penicillin G \xrightarrowk1 penicilloic acid \xrightarrowk2 secondary product<BR>is dominant with kinetic constants of k1=0.7×10−2 h−1 and k2=6×10−2 h−1.
Journal
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 50 (12), 3164-3166, 1977
The Chemical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679114633600
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- NII Article ID
- 130001970762
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- ISSN
- 13480634
- 00092673
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed
