Preparation of PLGA Microcapsules with Use of W/O Emulsion Droplets

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  • FUKUSHIMA Hiroshi
    Research Institute for Science and Technology, Faculty of Science and Technology, Tokyo University of Science
  • HASHINO Masachika
    Research Institute for Science and Technology, Faculty of Science and Technology, Tokyo University of Science
  • SAKAI Kenichi
    Research Institute for Science and Technology, Faculty of Science and Technology, Tokyo University of Science
  • SAKAI Hideki
    Research Institute for Science and Technology, Faculty of Science and Technology, Tokyo University of Science
  • KONDO Tamotsu
    Research Institute for Science and Technology, Faculty of Science and Technology, Tokyo University of Science
  • ABE Masahiko
    Research Institute for Science and Technology, Faculty of Science and Technology, Tokyo University of Science

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  • Ｗ／Ｏエマルションを利用したＰＬＧＡマイクロカプセルの調製
  • W O エマルション オ リヨウ シタ PLGA マイクロカプセル ノ チョウセイ

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Microcapsules have attracted much attention as a drug career. In the current study, we have prepared biodegradable poly (lactide-co-glycolide) (PLGA) microcapsules via the deposition of PLGA on W/O emulsion droplets. A combination of scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) demonstrates the formation of PLGA microcapsules with a diameter of 5∼10 μm. The formation mechanism of PLGA microcapsules is proposed on the basis of the experimental results.

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