Cladielloides C and D: Novel Eunicellin-Based Diterpenoids from an Indonesian Octocoral <i>Cladiella</i> sp.

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  • Tai Chia-Ying
    Graduate Institute of Marine Biotechnology, National Dong Hwa University National Museum of Marine Biology and Aquarium
  • Chen Yung-Husan
    National Museum of Marine Biology and Aquarium
  • Hwang Tsong-Long
    Graduate Institute of Natural Products, Chang Gung University
  • Fang Lee-Shing
    Department of Sport, Health, and Leisure, Cheng Shiu University
  • Wang Wei-Hsien
    National Museum of Marine Biology and Aquarium Department of Marine Biotechnology and Resources, National Sun Yat-sen University Asia-Pacific Ocean Research Center, National Sun Yat-sen University
  • Liu Ming-Chin
    National Museum of Marine Biology and Aquarium
  • Su Jui-Hsin
    Graduate Institute of Marine Biotechnology, National Dong Hwa University National Museum of Marine Biology and Aquarium
  • Wu Yang-Chang
    Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University Natural Medicinal Products Research Center, China Medical University Hospital
  • Sung Ping-Jyun
    Graduate Institute of Marine Biotechnology, National Dong Hwa University National Museum of Marine Biology and Aquarium Department of Marine Biotechnology and Resources, National Sun Yat-sen University Asia-Pacific Ocean Research Center, National Sun Yat-sen University Department of Life Science and Institute of Biotechnology, National Dong Hwa University

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  • Cladielloides C and D: Novel Eunicellin-Based Diterpenoids from an Indonesian Octocoral Cladiella sp.

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Chemical investigation on an Indonesian octocoral identified as Cladiella sp. has led to the isolation of two novel eunicellin-based diterpenoids, cladielloides C (1) and D (2). The structures of 1 and 2 were established by spectroscopic methods. Compound 1 exhibited significant cytotoxicity toward CCRF-CEM tumor cells and metabolites 1 and 2 displayed moderate inhibitory effects on superoxide anion generation by human neutrophils.

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