Therapeutic targets in the ASK1-dependent stress signaling pathways
-
- HAYAKAWA Ryoichi
- Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
- HAYAKAWA Teruyuki
- Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
- TAKEDA Kohsuke
- Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo Division of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University
-
- ICHIJO Hidenori
- Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
この論文をさがす
抄録
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family that activates downstream MAP kinases (MAPKs), c-Jun N-terminal kinases (JNKs) and p38 MAPKs, in response to various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide, and calcium overload. Activation of the JNK and p38 pathways induces stress responses such as cell death, differentiation, and the production of inflammatory cytokines. A series of studies using ASK1-deficient mice have indicated that ASK1 plays important roles in many stress-related diseases, including cardiovascular and neurodegenerative diseases, suggesting that small compounds that inhibit ASK1 activity could possibly be used for the amelioration of the development and/or progression of these diseases. In this review, we provide an overview of the pathophysiological roles of ASK1-dependent signaling pathways and discuss the mechanistic basis for how these could serve as potential therapeutic targets.<BR><BR>(Communicated by Takao SEKIYA, M.J.A.)
収録刊行物
-
- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
-
Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 88 (8), 434-453, 2012
日本学士院
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679121625728
-
- NII論文ID
- 130001924759
-
- NII書誌ID
- AA00785485
-
- COI
- 1:STN:280:DC%2BC3s%2Fks1ansQ%3D%3D
-
- ISSN
- 13492896
- 03862208
-
- HANDLE
- 10069/31142
-
- NDL書誌ID
- 024039135
-
- PubMed
- 23060232
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可