Expression of Borna Disease Virus Messages in Clinical Samples from Patients with Brain Malignant Tumors.
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- NAKAYA Takaaki
- Section of Serology, Institute of Immunological Science, Hokkaido University
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- TADA Mitsuhiro
- Department of Neurosurgery, Hokkaido University School of Medicine
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- TAKAHASHI Hirokazu
- Section of Serology, Institute of Immunological Science, Hokkaido University
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- FUJIWARA Suguru
- Section of Serology, Institute of Immunological Science, Hokkaido University
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- SAKUMA Shiro
- Department of Neurosurgery, Hokkaido University School of Medicine
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- SAWAMURA Yutaka
- Department of Neurosurgery, Hokkaido University School of Medicine
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- ABE Hiroshi
- Department of Neurosurgery, Hokkaido University School of Medicine
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- IKUTA Kazuyoshi
- Section of Serology, Institute of Immunological Science, Hokkaido University
Bibliographic Information
- Other Title
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- Expression of Borna Disease Virus Messa
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Abstract
Borna disease virus (BDV), a nonsegmented, negative-sense, single-stranded RNA virus with an envelope, was initially isolated from horses with poliomyeloencephalitis. BDV is also believed to be linked with psychiatric disorders in humans based on higher prevalences of serum antibodies against BDV and viral RNA footprints in peripheral blood mononuclear cells of psychiatric patients, compared with those of controls. Here, we show that BDV RNA was identified in total RNA extracted directly from clinical samples of brain tumors. We found that two and three samples were positive using primers for the p24 and p40 regions, respectively, among grade 4 malignant tumors (glioblastomas) from 16 patients. There were no positive samples among lower grades of tumors (pilocytic or anaplastic astrocytomas) from 21 patients at either region. Of particular note is the detection of either a p40 or a p24 RNA in each of the tumor samples. Thus, we detected BDV RNA for the first time in the brains of immunosuppressed patients.
Journal
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- Proceedings of the Japan Academy, Series B
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Proceedings of the Japan Academy, Series B 72 (7), 157-162, 1996
The Japan Academy
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Details 詳細情報について
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- CRID
- 1390282679121730048
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- NII Article ID
- 130000903691
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- NII Book ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL BIB ID
- 4109585
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed