Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6
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- AOYAGI TAKAAKI
- Institute of Microbial Chemistry
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- YOSHIDA SHIGEMI
- Institute of Microbial Chemistry
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- NAKAMURA YASUSHI
- Institute of Microbial Chemistry
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- SHIGIHARA YASUHIRO
- Institute of Microbial Chemistry
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- HAMADA MASA
- Institute of Microbial Chemistry
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- TAKEUCHI TOMIO
- Institute of Microbial Chemistry
書誌事項
- タイトル別名
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- Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
- I. TAXONOMY, PRODUCTION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES
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説明
Probestin has been isolated as part of a program designed to find microorganism-produced inhibitors of aminopeptidase M from Streptomyces azureus MH663-2F6. It was purified by use of column chromatography of Amberlite XAD-4, silica gel, YMC-gel, Toyopearl HW-40, YMC D-ODS-5 (HPLC) and then isolated as colorless powders. Probestin is competitive with the substrate, and the inhibition constant (Ki) of it was 1.9×10-8 M.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 43 (2), 143-148, 1990
公益財団法人 日本感染症医薬品協会
