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- HAMANAKA Sumiko
- Sphingolipid Expression Laboratory, Supra-biomolecular System Research, RIKEN Frontier Research System
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- SUZUKI Minoru
- Sphingolipid Expression Laboratory, Supra-biomolecular System Research, RIKEN Frontier Research System
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- SUZUKI Akemi
- Sphingolipid Expression Laboratory, Supra-biomolecular System Research, RIKEN Frontier Research System
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- YAMAKAWA Tamio
- Sphingolipid Expression Laboratory, Supra-biomolecular System Research, RIKEN Frontier Research System
書誌事項
- タイトル別名
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- Epidermosides
- Structure and function of skin-specific glycolipids
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抄録
Skin protects the human body from dryness and its molecular mechanism has been studied by both biological and biochemical approaches. The epidermis is the outer layer in skin and forms a water barrier. Animal experiments with diets deficient in essential fatty acids have demonstrated that lipids containing linoleic acid are essential molecules in the maintenance of the epidermal water barrier. Structural analysis revealed that linoleic acid-containing epidermal lipids include acylglucosylceramides, which are comprised of both very long chain ω-hydroxy fatty acids as the amide-linked fatty acids and linoleic acids as the esterified fatty acid linked through the ω-hydroxyl group. Human epidermis consists of two acylglucosylceramide groups, one containing sphingenine and the other containing phytosphingosine with a single double bond. We named these functional lipids“Epidermosides”. ω-Hydroxylation is the rate limiting biosynthetic step for the expression of these functional lipids and investigation of the hydroxylase active in this process is an important target for the further research.
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 77 (4), 51-56, 2001
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詳細情報 詳細情報について
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- CRID
- 1390282679122125184
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- NII論文ID
- 130000907948
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 5782202
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可